N.O. Limits by Designer Supplements 180 Capsules
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Nitric Oxide > Nitric Oxide Pills
Pre-Workout
Through the promotion of blood flow and positive nutrient partitioning, Nitric Oxide (NO) has found an elite place amongst bodybuilding and fitness enthusiasts looking to improve their physique. While some products merely doan adequate job of accomplishing this goal, the ideal NO product can produce a proverbial “skin-tearing” pump that provides the perfect physical and mental motivation for training; a product that makes you feel unstoppable in the gym. It is with this concept in mind that Designer Supplements introduces N.O. Limits, the evolutionary next step in Nitric Oxide signalling products.
Avoiding the trappings of unnecessary ingredients and proprietary blends, N.O. Limits is comprised of four primary ingredients with attached ethyl esters to enhance effectiveness, plus antioxidants to enhance safety and long term efficacy. Additionally, while the pump alone may be impressive enough for some, N.O. Limits combines Arginine Ethyl Ester with Lysine Ethyl Ester for the first time ever in an NO product to maximize natural growth hormone (GH) secretion.
Now, before we explain exactly why increased blood flow, increased nutrient uptake, long-lasting pumps, and maximized GH secretion can make an athlete feel as though there are N.O. Limits to what he or she can do, it is first our duty to explain how.
N.O. Limits, N.O. Nonsense
Traditional NO-boosting products use the NO precursor L-Arginine or a varied structure of this amino acid in order to provide substrate for NO conversion1. N.O. Limits not only provides the substrate using the new ethyl ester technology, it also utilizes compounds that control Nitric Oxide production while also providing anti-oxidants to control free radical release that Nitric Oxide and physical exercise can cause. By paying close attention to these details, N.O. Limits aims to not only prolong the efficacy of nitric oxide in users, but also potentially correct the fact that NO-boosters do not work in all users.
What is Nitric Oxide?
Nitric Oxide (NO) is a highly important signalling molecule in the body. Interestingly, it is a gas, and even more interesting is that it is also a free radical. While major research has recently indicated that NO is intimately related to brain, stomach, kidney, liver and lung function, the major interest bodybuilders and athletes have in NO is that it regulates blood flow and can influence nutrient uptake. Initially referred to as the Endothelium-Derived Relaxing Factor (EDRF), NO achieves its most tangible effect by causing the outer wall (the smooth muscle) of the blood vessel to relax and dilate. More specifically, NO binds to an enzyme known as guanylyl cyclase which catalyzes the conversion of Guanosine Triphosphate (GTP) to 3’,5’-cyclic Guanosine Monophosphate (cGMP). It is the cGMP that signals the smooth muscle to relax2. The net result of this reaction allows more nutrient-rich blood to travel through the artery thereby causing the effect commonly known as the “pump”. Not only is the pump mentally motivating, but there is also speculation that it may promote
increased protein synthesis in the stressed muscle3, and may increase creatine synthesis4.
In summary, N.O. Limits is the best choice of NO-promotion available today, and is excellent for:
- Promoting workout “pumps”
- Improving blood flow
- Increasing nutrient uptake • Maximizing hGH release
- Positive Mental motivation
N.O. Limits can be stacked with XCEED to form the perfect pre-workout cocktail that will maximize your performance as you train, and promote your recovery as you rest. The addition of Replenish post workout along with Glucophase XR confers added benefit in terms of nutrient partitioning, active recovery, and maximal cellular signalling to ensure the best results of each and every workout. Going to the gym should be about maximum results for your effort and it is for this reason that you should set N.O. Limits to your expectations.
For best results, take one serving of N.O. Limits 30 minutes prior to workout. Use N.O. Limits for no longer than eight weeks at a time before cycling off for six to eight weeks.
Q) How many servings per bottle of N.O. Limits?
(A) 30.
(Q) How long will a bottle last?
(A) If you trained every day and used it before each workout, exactly thirty days. Not everyone does this (we hope!), so if you train 4-5 days a week, each bottle will last a month and a half to two months.
(Q) So I shouldn’t take N.O. Limits on off days?
(A) No, that is not necessary.
(Q) When should I take it?
(A) 30-45 minutes before training.
(Q) How long should I take it for?
(A) At least a four-week cycle. Use N.O. Limits for no longer than eight weeks at a time before cycling off for four to eight weeks.
(Q) Should I stack it with anything?
(A) It is not necessary.. no. However, combining N.O. Limits with XCEED before training will provide an excellent pre-workout stack. Together, they will combine for an in-gym experience like you have never experienced. They will provide energy, increase endurance, improve pumps and motivate you to have your best workouts ever. The will also trigger the anabolic response to your training, and improve recover – particularly if you take REPLENISH after your workout.
(Q) How would this compare to XCEED?
(A) They are very different products, so you cannot compare. XCEED does contain di-arginine malate which promotes nitric oxide elevation, but it is not solely (or even primarily) an NO-boosting product. It also caters for energy, endurance and strength. N.O. Limits targets NO elevation and GH release, making it a superior product for this specific objective. Combining them gets the best of both worlds.
(Q) Is this a time-release product?
(A) Not in the true sense of the word, no. But we have included compounds and their metabolites that can be plugged into a cycle and can convert back and forth to a certain degree.
(Q) What exactly is Nitric Oxide?
(A) Nitric Oxide (NO) is a highly important signalling molecule in the body. It appears to be connected to brain, stomach, kidney, liver and lung regulation. It also regulates blood flow and can influence nutrient uptake. It achieves this effect by causing the outer wall (the smooth muscle) of the blood vessel to relax and dilate. Allowing more blood to engorge the muscle results in what is referred to as “pumps”. The more blood, the greater the pump.
(Q) How strong will the pumps be for this product?
(A) Its hard to say because sensitivity ranges between individuals. However, we are very confident in saying, that because we have designed the product to cater for reasons why NO-boosting products do not work for every user, N.O. Limits is one of, if not the best NO-enhancing product available on the market.
(Q) All NO-boosting products contain Arginine in some form of other. Why this particular amino acid?
(A) Because its conversion to citrulline releases NO.
(Q) If Arginine converts to citrulline, why include citrulline ethyl ester in N.O. Limits?
(A) Because the citrulline can be converted back into Arginine. In fact, citrulline is the rate-limiting factor for Arginine synthesis in the kidneys, so it makes a lot of sense to include it.
(Q) So why include Ornithine?
(A) Like Arginine and citrulline, it is part of the urea cycle. This cycle helps dispose of toxic ammonia build-up from various metabolic processes (including respiration, which is jacked-up during training). Ammonia build-up can hinder endurance and alter cell pH making you burn out quicker during a set. Including the intermediates of the cycle limits any one of them becoming rate-limiting. This also means a constant stream of nitric oxide is released.
(Q) Is lysine part of the same cycle?
(A) No. Lysine is included in N.O. Limits due to the promoting effect it has on growth hormone (hGH) release when used in combination with Arginine. In a step never taken by any other company before, N.O. Limits uses this combination in their ethyl ester form for increased bioavailability. While questions may be raised about how effective or significant this rise in hGH may be, its effects upon stimulating protein synthesis, bone strengthening and lipolysis (fat burning) are certainly welcomed.
(Q) I don’t understand why you include an antioxidant in the product. Could this space in the product not have been used for more NO-boosting compounds?
(A) Maybe, but we have included the antioxidant N-Acetyl-Cysteine (NAC) for several reasons. As noted above, we have catered for the reasons why some people simply do not respond to NO-boosting products. Glutathione is the body’s main natural antioxidant, and its reserves appear to be depleted for NO production and nitrate disposal. It is theorized that as glutathione reserves drop, as does the body’s ability to create NO.
Not only this, but exercise increases free radical activity. Free radicals can inhibit protein synthesis, be detrimental to health, and even inhibit the enzyme that converts Arginine to citrulline (the process of which gives of NO). So long as NO production is kept in balance with the increase in radicals, beneficial effects are noted. If not, detrimental effects are noted. The key to controlling this balance is through use of anti-oxidants.
(Q) So why not any other anti-oxidant?
(A) Because NAC is a great compound, supplying acetyl groups that can be used in the Krebs cycle for ATP production, and also cysteine, which is the precursor to glutathione – the body’s best anti-oxidant.
(Q) Should I use any other antioxidants with N.O. Limits?
(A) R-Alpha Lipoic Acid is interesting as not only does it have anti-oxidant effect against free radicals, it may also promote activity of the enzyme that converts Arginine to citrulline in the blood vessels. Glucophase XR has R-Alpha Lipoic Acid in a stable potassium form, making it perfect for use with N.O. Limits. The soon-to-be-released Insutrol also contains a form of R-Alpha Lipoic Acid and is also a great addition.
(Q) For bodybuilders, does NO do anything besides give a pump?
(A) As noted above, it is an important cell-signalling molecule. By promoting blood flow it can aid with nutrient uptake, and has even been linked with the raise in protein synthesis (growth) rates that follow training - possibly due to an effect on satellite cell proliferation in the muscle (an event that occurs to trigger the creation of new proteins).
Forcing more blood into the muscle provides more of a cushion and may even help burst through a plateau. It must not be ignored how mentally motivating a pump is, especially when it feels like your skin is about to tear.
(Q) I have a medical condition. Can I use N.O. Limits?
(A) Always consult your physician before using a new dietary supplement
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