What is
Nitro Loading?
New developments in the oral administration of Creatine monohydrate are going to have a
major impact on the future of sports supplementation. MHP's staff of biochemists along
with leading scientists in pharmaceutical time-release delivery have created a compound
that enhances the delivery of Creatine to skeletal muscle leading to increased muscle size
and strength. This revolutionary compound, TRAC™, increases the production of
Nitric-Oxide (NO) in the body. Research shows that Nitric Oxide stimulates insulin output
and sensitivity without the addition of carbohydrates. This new approach to mediate
insulin is called "Nitro-Loading".
TRAC™ is the first "Nitro-Loading" Creatine product ever developed.
TRAC™ uses a patent pending micro-encapsulation time-release system, TRT™,
to deliver its two primary substrate compounds Arginine and Creatine. TRAC's™
proprietary delivery system increases the bioavailability of Arginine and Creatine
releasing them, as they are needed. By prolonging the delivery and enhancing the
bioavailability of these compounds, not only are athletes who perform short explosive
tasks like bodybuilders, power lifters and sprinters going to benefit, but for the first
time, endurance athletes are also going to benefit from creatines performance enhancing
properties. TRAC™ is the first and only product on the market with the exclusive TRT™
Nitro-Loading transport. We believe this may be the biggest breakthrough in sports
supplements to date. These developments are going to render all other current Creatine
products obsolete.
How
Time Released Nitro Loading works...
In order to fully understand how Nitro-Loading works and why it is far superior to any
other form of loading we must examine how oral immediate release Creatine Monohydrate and
other loading administration is utilized by the body.
Creatine Monohydrate is transported by the blood and taken up by muscle cells where it
is converted into Creatine phosphate. The enzyme responsible for this conversion is
Creatine kinase. As Creatine cycles back and forth between Creatine and Creatine
phosphate, it produces energy to the muscle cell but only briefly.
This immediate burst of energy has an extremely short half-life of about 15 seconds.
Dietary supplementation with large amounts of Creatine, or Creatine loading, has been one
way of attempting to overcome the quick exhaustion of Creatine stores when there is
intense and prolonged activation of muscles during athletic activity or weight training.
It is believe that by loading the muscles with extra Creatine, more Creatine would be
available for energy production by the muscles after the initial exhaustion of Creatine
reserves. The common prescribed dose during the loading phase is 5 grams four times a day
(20 grams total) for 4 days followed by a 5-gram maintenance dose for eight to ten weeks.
But the amount of Creatine present in muscle cells can saturate the sodium transport
system responsible for enabling more Creatine to enter the muscles, reducing the flow of
new Creatine because already present Creatine stores are blocking the diffusion
gradient. Consuming more immediate-release Creatine does not necessarily push more
Creatine into the muscles because it can shut down the sodium pump responsible for
shuttling the Creatine into muscle to begin with. In addition, a high Creatine
concentration will down-regulate muscle Creatine transport.
Why
TRAC's Sugar Free delivery is superior?
Further research on immediate release Creatine loading showed even more evidence against
its effectiveness. One study showed that administering a loading phase followed by a 5
gram per day maintenance phase had no greater effect on Creatine in muscle after 30 days,
than administering 5 grams per day with no loading phase. It has also been determined that
most people can only store 2 to 3 grams of Creatine in the skeletal muscles. So, any thing
more is likely being excreted thru urine or feces.
Later research did however show that Creatine accumulation could be
substantially increased in skeletal muscles when ingested with large quantities of simple
sugars. A 94-gram dose of carbohydrates in the form of glucose and simple sugars was
needed with each 5-gram dose of Creatine to increase muscle Creatine by about 25%. This
effect is believed to be related to carbohydrate-mediated insulin release, which
presumably would stimulate sodium-dependant muscle Creatine transport.
The problem is, consuming 94 grams of sugar defies all sports nutrition principles and
is far too much to be physiologically acceptable for repeated use. Consuming such large
quantities of sugars can have many negative side effects on health and physical
performance, including energy crashes and increased body fat.
TRAC™ eliminates these negative effects by using TRT™ Arginine as its insulin
mediating substance instead of large amount of carbohydrates. L-Arginine is a precursor
for the formation of Nitric-Oxide (N0). Researchers and scientists have been studying
Nitric-Oxides involvement in a number of physiological processes. New research has shown
that Nitric Oxide can have a substantial effect on insulin release and sensitivity, blood
flow, nutrient delivery and protein synthesis.
The effects
of Arginine and
Nitric Oxide on Creatine transport.
Fairly large doses of Arginine are required to enhance Nitric-Oxide (N0) production or
stimulate insulin release. The majority of studies conducted with L-Arginine that relate
to the benefits of Nitric-Oxide production or insulin-mediated vasodilatation have either
involved intravenous administration or oral administration of immediate release
formulations in repeated doses throughout the day. Single large dosages of Arginine are
not well tolerated and may cause stomach discomfort and diarrhea. In a pilot study,
subjects given 4 grams of L-Arginine freebase experienced bowel intolerance and diarrhea
within a few hours. After a two-week washout, the same subjects were given the same 4-gram
dose again with the same results. Diarrhea speeds up gastric emptying and shortens transit
time for solutes in the window of absorption.
Surprisingly, when the same subjects were given TRT™ Arginine, greater absorption
was possible due to reduced bowel intolerance. In this way less L-Arginine is lost to
diarrhea, and more is absorbed for vasodilatation or production of nitric oxide. TRT™
not only increases the tolerated amount of oral dosages but also prolongs the supply of
Arginine to stimulate insulin release.
MHP has discovered that by incorporating Arginine with Creatine, muscle Creatine stores
can be increased. An even more effective formulation for accomplishing Creatine muscle
transport and accumulation is the combination of (TRT™) time-release Arginine
with (TRT™) time-release Creatine. Time-release Arginine is more effective
because more Arginine substrate is made available through better absorption in the
gastrointestinal tract. Therefore, more substrate is available for the production of
nitric oxide mediated insulin, which stimulates better Creatine transport to and
accumulation in muscle. Furthermore, by coupling the slow presentation of both substances
simultaneously, a type of nitric oxide shuttle for more effective delivery of Creatine to
muscle is provided.
By slowing down the rate of presentation of the Creatine to the liver and the muscles,
especially during intense exercise or bodybuilding workouts, the need for normal Creatine
loading, which is inefficient, is avoided. Instead, the supply of Creatine is constant,
and is not working against a concentration gradient for entry to muscle. The slow, long
term supply of Creatine, which spans many hours of exercise activity, provides a metered
injection of Creatine as it is exhausted from muscle stores. This type of system is more
effective during intense muscular activity than during sedentary periods because of the
increased catabolism of Creatine to creatinine.
By slowing down the rate of increased substrate availability of a nitric oxide and
insulin mediating substance such as Arginine, prolonged vasodilatation can be achieved.
Instead of a sudden burst of nitric oxide and concomitant decay, long term conversion to
NO or stimulation of insulin release can occur. Likewise, long term vasodialatory effect
from insulin and a sustained increased in blood supply drives Creatine and other nutrient
and energy rich co-factor availability to skeletal muscle. This increased blood flow and
nutrient delivery to muscles can provide tremendous benefits to endurance athletes.
Nitric Oxide also functions as an anti-oxidant. Intense exercise increases production
of reactive oxygen species (damaging free radicals). Creatine kinase, the enzyme
responsible for conversion of Creatine to phosphocreatine (Creatine phosphate), is
oxidized (inactivated) by free radicals. The anti-oxidant properties of nitric oxide
enhancement via increased supply of supplemental L-Arginine should serve to extend and
prolong the integrity of Creatine kinase, and thereby facilitate the cycling of Creatine
to phosphocreatine. This should enhance Creatine stores in muscle cells, and provide a
better environment for the entire process.
Aside from being the most advanced Creatine transport product ever developed,
TRAC™ also provides many additional muscle building and physiological benefits.
TRAC's™ time-released Nitro-Loading properties also improve the absorption of other
nutrients. That's Right! TRAC's™ sustained production of Nitric Oxide can increase
nutrient delivery (specifically amino acids) to working muscles. So, any other supplements
you are taking, especially proteins, are going to be better utilized by the body. This is
definitely an added bonus for bodybuilder and athletes.
I'm sure once other supplement companies learn of the amazing physiological effects of
TRAC's™ Nitro-Loading; they will try to copy this extraordinary compound. However,
TRAC's™ unique patent pending formulation and manufacturing process will prevent
others from being able to copy this sophisticated technology.
The Importance of
NADH...
Another major component of TRAC™ is NADH (nicotinamide adenine dinucleotide). Its
role as an anti-oxidant helps to preserve NO and suppress superoxide anion and
peroxynitrate production. Aside from its role as an anti-oxidant, this powerful co-enzyme
of niacin influences many important biological functions in the body including; the
production of ATP, cell regulation and DNA repair, and stimulation of dopamine,
adrenaline, and norephinephrine production.
NADH is often referred to as the energy nutrient. NADH is used by the body for the
synthesis of ATP, the energy compound in every living cell. Studies conducted among
competitive-level athletes and long-distance runners taking NADH showed significant
improvements in performance. This increased synthesis of ATP coupled with the increased
production of ATP from Creatine is of a tremendous benefit to both power and endurance.
Other added
benefits of TRAC™...
Aside from being the most advanced Creatine transport
product ever developed, TRAC™ also provides many additional muscle building and
physiological benefits. TRAC's™ time-released Nitro-Loading properties also improve
the absorption of other nutrients. That's Right! TRAC's™ sustained production of
Nitric Oxide can increase nutrient delivery (specifically amino acids) to working muscles.
So, any other supplements you are taking, especially proteins, are going to be better
utilized by the body. This is definitely an added bonus for bodybuilder and athletes.
I'm sure once other supplement companies learn of the amazing physiological effects of
TRAC's™ Nitro-Loading; they will try to copy this extraordinary compound. However,
TRAC's™ unique patent pending formulation and manufacturing process will prevent
others from being able to copy this sophisticated technology.
If you want to elevate your physique and performance to a higher level, you better GET
ON TRAC™. TRAC™, "the highest level of supplementation".
Ingredients:
maltodextrin, Citric Acid, Natural and Artificial
Lemon-Lime Flavor, Sucralose, Acesulfame-K, Vegetable Oil, Folic acid, Yellow #5.
Product Directions: Serving Size is
17 grams or 1 heaping tablespoon. Take one serving
daily, preferably pre-workout. Mix with 8 oz. of water and stir vigorously.
We recommend using a shaker bottle for the best mix!
CRITICAL INFORMATION
NO marketing
hype, just the facts
Unlock
your NITRIC OXIDE potential with proven L-ARGININE
vs.
#1
"NO2"
or "NO" stands for "Nitric Oxide". Nitric Oxide is
responsible for Hemodilation (the pump), cell signaling and increased
nutrient uptake.
#2
All
clinical studies on boosting "Nitric Oxide" production in the
body were done with L-ARGININE and NOT AAKG.
#3
NO2 uses 1,500mg of AAKG
that equals approximately 750mg of L-Arginine while TRAC uses 4,000mg of
clinically proven pure L-Arginine. This makes TRAC 5 times more powerful
and effective at creating incredible pumps and muscle gains.
#4
TRAC's
orginal Time Release Technology (TRTTM)
keeps your pump for up to 8 hours and is so effective that it was
awarded a U.S. Patent from the government.
#5
TRAC
also contains 4 grams of Creatine and other critical nutrients to further
enhance your pump, strength and workout energy.
The World's First Time-Released Creatine
Time-Released
Arginine/Creatine
PATENTED TECHNOLOGY
Latest Scientific Information!
NO2
Overview
Some
of you may be wondering about the safety and efficacy of a new
ingredient called arginine alpha ketoglutarate (AAKG). This is a
synthetic molecule that has been made in the laboratory and does not
naturally exist in foods. While it contains arginine, the amount of
arginine is significantly less than the free from amino acid L-arginine.
This is because the arginine in AAKG is attached to the ketoglutarate
moiety. a-ketoglutarate
(a-KG) is an intermediary in the Krebs cycle and
is synthesized from oxalosuccinate and gives rise to succinyl-CoA.
Technically AAKG would be called a a-keto
analog of arginine. An analog is a synthetic drug that is man made.
While
it is possible that the a-keto
analog of L-arginine (AAKG) could be formed in-vivo, researchers believe
that this could only happen due to certain abnormalities of amino acid
metabolism that have been observed in patients with inborn enzymatic
defects or blockage of the urea cycle.
There is some indication that there may be potential toxicity of the
cyclic forms of the a-keto
acids due to accumulation under certain conditions, but without animal
feeding studies or dose response studies, the safety profile of AAKG is
unknown.
______________________________________________________________________
There
are many studies demonstrating the conversion of L-arginine to nitric
oxide and the beneficial effects of NO on the cardiovascular system, but
there are no published studies related to arginine a-ketoglutarate
and nitric oxide.
____________________________________________________________
While
there have been numerous studies done related to the effects of the free
form amino acid L-arginine on nitric oxide production in the
endothelium, as well as pharmacokinetcs/pharmacodynamic studies, there
are no published studies relating to the effects of arginine alpha
ketogluterate (AAKG) on nitric oxide production. L-arginine exerts many
beneficial effects on the cardiovascular system, and is a wound healing
and immune system stimulating agent. The beneficial effects of L-arginine
have been studied in dose response studies where blood levels have been
correlated with pharmacodynamic effects such as vasodilatation or
increased blood flow to the legs and forearms. In addition, many safety
studies have been conducted with free form L-arginine. Pure L-arginine
has been administered by infusion (IV) and orally at very high doses (30
grams/day) without toxicity. These studies have demonstrated that fairly
high doses of L-arginine are needed to drive nitric oxide production in
the arteries. There are many published studies that have measured the
production of nitric oxide by L-arginine both in-vitro and in-vivo.
_______________________________________________________________________
AAKG
contains less actual arginine than free from L-arginine
_____________________________________________________________
Since
AAKG contains one molecule of a-ketogluterate
combined with either one or two molecules of arginine, the amount of
actual L-arginine contained in AAKG is from 1/3 to 2/3 less than the
equivalent weight of L-arginine itself. That means that for every gram
of AAKG consumed, only 300 to 600 mg. of arginine would be available.
For example, a 1,500 mg. dose of AAKG would contain only 450 to 900 mg.
of actual arginine. Studies indicate that this may not be enough
arginine to cause a significant effect on nitric oxide production.
_______________________________________________________________________
AAKG
is metabolized to L-glutamine and glutamate. L-glutamine actually
decreases nitric oxide synthesis from L-arginine, and glutamate may be
toxic to the brain.
_____________________________________________________________
Once
ingested, aKG
is metabolized by the body to glutamate and glutamine. This metabolism
can be described as follows; a-KG is aminated or transaminated into
glutamate, which in turn is aminated into glutamine by a reaction
catalyzed by glutamine synthase
L-glutamine inhibits nitric oxide (NO) synthesis in the endothelial
(inner lining of blood vessels) cells in a concentration-dependent
manner.
Taken together, the fact that one of the principle metabolites of AAKG
is L-glutamine, and that L-glutamine inhibits nitric oxide (NO)
synthesis from L-arginine, it would appear that the effect of AAKG on NO
would be cancelled out. Using AAKG to drive NO does not appear to be a
viable strategy, because the metabolism of the AAKG complex will inhibit
the ability of the L-arginine component to produce nitric oxide because
the metabolic end products of AAKG result in antagonism of nitric oxide
production by L-glutamine. Ideally, if one were taking an L-glutamine
supplement, it would be advisable to take an L-arginine supplement at a
different time (not concurrently.
